Persistent long-term platelet activation and endothelial perturbation in women with Takotsubo syndrome

Takotsubo (TTS) syndrome is an acute cardiac condition characterized by transient and reversible left ventricle dysfunction that mainly affects postmenopausal women. Catecholamine burst the most accredited mechanism underpinning TTS onset leading to endothelial platelet activation. Even if use of low dose acetylsalycilic acid (ASA) in this clinical setting based on both presentation unfavorable long-term prognosis, its efficacy has been recently challenged. This study was designed assess function, residual thromboxane formation aggregation women low-dose ASA treatment at follow-up. Twenty-eight females with previously diagnosis were enrolled. Data compared those obtained from 23 coronary artery disease (CAD) a history myocardial infarction, 26 control subjects no or clinically evident CAD. Psychological profile assessed all groups enrollment. Main metabolites involved L-arginine/nitric oxide pathway, urinary prostacyclin, serum urine measured LCMS/MS methods. Thrombomodulin levels quantified using ELISA kit, aggregation, carried out rich-plasma, induced ADP epinephrine (EPI), norepinephrine (NORE) TRAP-6, alone association evaluated Born’s method. In derangement, reduced citrulline production increased thrombomodulin concentration, perturbation prostacyclin levels, evidenced. addition, despite treatment, displayed higher formation, parallel enhanced response Our highlighted presence patients even index event. The still leave open question about setting.